Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a unique …

Primordial germ cells (PGCs) are the embryonic precursors of the gametes and represent
the founder cells of the germline. Specification of PGCs is a critical divergent point during …

Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state.
However, without a tractable experimental model, the mechanism of human PGC (hPGC) …

Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for development.
We show that the transcriptional program of hPGCs is distinct from that in mice, with co-…

Germ cells are unique cell types that generate a totipotent zygote upon fertilization, giving
rise to the next generation in mammals and many other multicellular organisms. How germ …

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during
weeks 2–3 of early post-implantation development 1 . Using in vitro models of hPGC …

Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in
unipotent primordial germ cells (PGCs) in mice 1 , where its precise role is yet unclear 2 , 3 , 4 …

Retinoic acid, an active metabolite of vitamin A, plays essential signaling roles in mammalian
embryogenesis. Nevertheless, it has long been recognized that overexposure to vitamin A …

High-resolution molecular programmes delineating the cellular foundations of mammalian
embryogenesis have emerged recently. Similar analysis of human embryos is limited to pre-…

Germline–soma segregation is a fundamental event during mammalian embryonic
development. Here we establish the epigenetic principles of human primordial germ cell (hPGC) …