Cells are highly complex and orderly machines, with defined shapes and a startling variety
of internal organizations. Complex geometry is a feature of both free-living unicellular …

Recently, there has been a surge in the number of pioneering studies combining experiments
with quantitative modeling to explain both relatively simple modules of molecular …

Basal bodies are modified centrioles that give rise to cilia and flagella. The basal body is a
complex structure that can form through at least two distinct pathways depending on the cell …

Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land
plants over 1 billion years ago. It is a model system for studying chloroplast-based …

The cilium is a complex organelle, the assembly of which requires the coordination of motor-driven
intraflagellar transport (IFT), membrane trafficking and selective import of cilium-…

A central question in cell biology is how cells determine the size of their organelles. Flagellar
length control is a convenient system for studying organelle size regulation. Mechanistic …

Chromosome movements and spindle dynamics were visualized in living cells of the
budding yeast Saccharomyces cerevisiae. Individual chromosomal loci were detected by …

Position–effect variegation (PEV) describes the stochastic transcriptional silencing of a gene
positioned adjacent to heterochromatin. Using FISH, we have tested whether variegated …

In addition to the popular method of fluorescent protein fusion, live cell protein imaging has
now seen more and more application of epitope tags. The small size of these tags may …

In the developing mouse embryo, leftward fluid flow on the ventral side of the node determines
left–right (LR) asymmetry. However, the mechanism by which the rotational movement of …