The successful design of nanofluidic devices for the manipulation of biopolymers requires
an understanding of how the predictions of soft condensed matter physics scale with device …

DNA is the central storage molecule of genetic information in the cell, and reading that
information is a central problem in biology. While sequencing technology has made enormous …

We show that genomic-length DNA molecules imaged in nanochannels have an extension
along the channel that scales linearly with the contour length of the polymer, in agreement …

Here we explore the potential power of denaturation mapping as a single-molecule
technique. By partially denaturing YOYO®-1-labeled DNA in nanofluidic channels with a …

We show that arrays of nanopit structures etched in a nanoslit can control the positioning
and conformation of single DNA molecules in nanofluidic devices. By adjusting the spacing, …

A nanofluidic device is presented that, enables independent sensing and resensing of a
single DNA molecule translocating through two nanopores with sub‐micrometer spacing. The …

We show that the ionic environment plays a critical role in determining the configurational
properties of DNA confined in silica nanochannels. The extension of DNA in the nanochannels …

We demonstrate a confinement spectroscopy technique capable of probing small
conformational changes of unanchored single DNA molecules in a manner analogous to force …

We have performed single-molecule studies of GFP–LacI repressor proteins bound to
bacteriophage λ DNA containing a 256 tandem lac operator insertion confined in nanochannels. …

Extracellular vesicles (EVs) are continually released from cancer cells into biofluids, carrying
actionable molecular fingerprints of the underlying disease with considerable diagnostic …