Voltage sensors containing the charged S4 membrane segment display a gating charge vs.
voltage (Q–V) curve that depends on the initial voltage. The voltage-dependent …

Ibogaine, a hallucinogenic alkaloid proposed as a treatment for opiate withdrawal, has
been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other …

The nonmedical use of synthetic cathinones is increasing on a global scale. 4-Methyl-N-methylcathinone
(mephedrone) is a popular synthetic cathinone that is now illegal in the United …

The physiological function of neurotransmitter transporter proteins like the serotonin
transporter (SERT) is reuptake of neurotransmitter that terminates synaptic serotoninergic …

Serotonin (5-HT) uptake by the human serotonin transporter (hSERT) is driven by ion
gradients. The stoichiometry of transported 5-HT and ions is predicted to result in electroneutral …

Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin
transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT …

The serotonin transporter (SERT) removes synaptic serotonin and is the target of anti-depressant
drugs. SERT adopts three conformations: outward-open, occluded, and inward-open. …

Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of
depression and anxiety-related disorders, eg, social phobias and post-traumatic stress disorder. …

Psychostimulants interacting with the dopamine transporter (DAT) can be used illicitly or for
the treatment of specific neuropsychiatric disorders. However, they can also produce severe …

Determining the structural elements that define substrates and inhibitors at the monoamine
transporters is critical to elucidating the mechanisms underlying these disparate functions. In …