Cytokines are secreted proteins that regulate important cellular responses such as
proliferation and differentiation 1 . Key events in cytokine signal transduction are well defined: …

Mixed lineage kinase domain-like (MLKL) is a component of the "necrosome," the multiprotein
complex that triggers tumor necrosis factor (TNF)-induced cell death by necroptosis. To …

Members of the suppressor of cytokine signaling (SOCS) family are potentially key physiological
negative regulators of interleukin-6 (IL-6) signaling. To examine whether SOCS3 is …

Mice lacking suppressor of cytokine signaling-1 (SOCS1) develop a complex fatal neonatal
disease. In this study, SOCS1 −/− mice were shown to exhibit excessive responses typical of …

The four members of the recently identified suppressor of cytokines signaling family (SOCS-1,
SOCS-2, SOCS-3, and CIS, where CIS is cytokine-inducible SH2-containing protein) …

Many cytokines exert their biological effect through members of the hemopoietin receptor
family. Using degenerate oligonucleotides to the common WSXWS motif, we have cloned from …

▪ Abstract Cytokines are an integral component of the adaptive and innate immune responses.
The signaling pathways triggered by the engagement of cytokines with their specific cell …

One of the most common analysis tasks in genomic research is to identify genes that are
differentially expressed (DE) between experimental conditions. Empirical Bayes (EB) statistical …

The suppressors of cytokine signalling (SOCS) are a family of intracellular proteins, several
of which have emerged as key physiological regulators of cytokine responses, including …

To search for genes that can collaborate with myc in lymphomagenesis, we exploited
retroviral insertional mutagenesis in Ep-myc transgenic mice. Moloney murine leukemia virus …