Many bacterial pathogens express lipooligosaccharides that mimic human cell surface
glycoconjugates, enabling them to attach to host receptors and to evade the immune response. In …

Using site‐directed mutagenesis we have investigated the catalytic residues in a xylanase
from Bacillus circulans. Analysis of the mutants E78D and E172D indicated that mutations in …

The 20 kDa xylanase from Bacillus circulans carries out hydrolysis of xylan via a two-step
mechanism involving a covalent glycosyl−enzyme intermediate. In this double-displacement …

We have compared the lipo-oligosaccharide (LOS) biosynthesis loci from 11 Campylobacter
jejunistrains expressing a total of 8 different ganglioside mimics in their LOS outer cores. …

Protein glycosylation is ubiquitous throughout biology. From bacteria to humans, this post
translational modification with sophisticated carbohydrate structures plays a profound role in …

We have applied two strategies for the cloning of four genes responsible for the biosynthesis
of the GT1a ganglioside mimic in the lipooligosaccharide (LOS) of a bacterial pathogen,…

Ganglioside mimicry by Campylobacter jejuni lipo‐oligosaccharide (LOS) is thought to be a
critical factor in the triggering of the Guillain–Barré and Miller–Fisher syndrome neuropathies …

Engineering of glycosyltransferases (GTs) with desired substrate specificity for the synthesis
of new oligosaccharides holds great potential for the development of the field of glycobiology…

When fed to a β-galactosidase-negative (lacZ – ) Escherichia coli strain that was grown on
an alternative carbon source (such as glycerol), lactose accumulated intracellularly on …

We recently demonstrated that Campylobacter jejuni produces a capsular polysaccharide (CPS)
that is the major antigenic component of the classical Penner serotyping system …