The discovery that drugs targeting a single G protein-coupled receptor (GPCR) can differentially
modulate distinct subsets of the receptor signaling repertoire has created a challenge …

Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific
conformations that activate only subsets of signaling effectors. In this study, to identify …

Understanding the organization of the cell cycle has been a longstanding goal in cell biology.
We combined time-lapse microscopy, highly multiplexed single-cell imaging of 48 core cell …

The cellular decision governing the transition between proliferative and arrested states is
crucial to the development and function of every tissue. While the molecular mechanisms that …

The β 2 adrenergic receptor (β 2 AR) increases intracellular Ca 2+ in a variety of cell types.
By combining pharmacological and genetic manipulations, we reveal a novel mechanism …

Introduction: In recent years, it has become clear that individual GPCRs can elicit multiple G-protein-dependent
and -independent cellular responses. This has led to the discovery that …

The ability of cells to adapt their response to growth factors in relation to their environment is
an essential aspect of tissue development and homeostasis. We found that signaling …

The proto-oncogenic epidermal growth factor receptor (EGFR) is a tyrosine kinase whose
sensitivity to growth factors and signal duration determines cellular behavior. We resolve how …

Growth factor–dependent vesicular dynamics allow cells to regulate the spatial distribution
of growth factor receptors and thereby their coupling to downstream signaling effectors that …

The CDK4/6 inhibitor palbociclib blocks cell cycle progression in Estrogen receptor–positive,
human epidermal growth factor 2 receptor–negative (ER+/HER2−) breast tumor cells. …