Neurobiology of speech and language has previously been studied in the KE family, in
which half of the members have severe impairment in both speech and language. The gene …

Macrophages have a critical role in inflammatory and immune responses through their ability
to recognize and engulf apoptotic cells 1 . Here we show that macrophages initiate a cell-…

Epithelial gene expression in the lung is thought to be regulated by the coordinate activity of
several different families of transcription factors including the Fox family of winged-helix/…

Although the Wnt signaling pathway regulates inductive interactions between epithelial and
mesenchymal cells, little is known of the role that this pathway plays during lung …

Branching morphogenesis in the lung serves as a model for the complex patterning that is
reiterated in multiple organs throughout development. β-catenin and Wnt signaling mediate …

The airways of the lung develop through a reiterative process of branching morphogenesis
that gives rise to the intricate and extensive surface area required for postnatal respiration. …

Wnt7b is a Wnt ligand that has been demonstrated to play critical roles in several
developmental processes, including lung airway and vascular development and chorion-allantois …

In this study, we find that WNT7b is the only member of the WNT family of autocrine/paracrine
signaling molecules whose expression in the lung is restricted to the airway epithelium …

Animal models with genetic modifications under temporal and/or spatial control are invaluable
to functional genomics and medical research. Here we report the generation of tissue-…

The proximal‐distal patterning of lung epithelium involves a complex series of signaling and
transcriptional events resulting in the programmed differentiation of highly specialized cells …