Although CDKN2A is the most frequent high-risk melanoma susceptibility gene, the
underlying genetic factors for most melanoma-prone families remain unknown. Using whole-exome …

Mammalian telomeres end in single-stranded, G-rich 3′ overhangs resulting from both the "end-replication
problem" (the inability of DNA polymerase to replicate the very end of the …

DNA damage is caused by either endogenous cellular metabolic processes such as
hydrolysis, oxidation, alkylation, and DNA base mismatches, or exogenous sources including …

Efficient and faithful replication of telomeric DNA is critical for maintaining genome integrity.
The G‐quadruplex (G4) structure arising in the repetitive TTAGGG sequence is thought to …

The proper maintenance of telomeres is essential for genome stability. Mammalian telomere
maintenance is governed by a number of telomere binding proteins, including the newly …

G-rich 3′ telomeric overhangs are required both for forming the distinct telomere structures
to protect chromosome ends and for extending telomeres by telomerase. However, little is …

Telomere length maintenance, an activity essential for chromosome stability and genome
integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein …

Accurate DNA replication is essential for maintaining genome stability. However, this stability
becomes vulnerable when replication fork progression is stalled or slowed – a condition …

The human CST (CTC1-STN1-TEN1) complex is an RPA-like single-stranded DNA binding
protein complex. While its telomeric functions have been well investigated, numerous studies …

Telomere maintenance is critical for genome stability. The newly-identified Ctc1/Stn1/Ten1
complex is important for telomere maintenance, though its precise role is unclear. We report …