Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving
aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of …

Quantification of the effect of spatial tumour sampling on the patterns of mutations detected
in next-generation sequencing data is largely lacking. Here we use a spatial stochastic …

Frequency-dependent selection and demographic fluctuations play important roles in evolutionary
and ecological processes. Under frequency-dependent selection, the average fitness …

Trade-offs play an important role in evolution. Without trade-offs, evolution would maximize
fitness of all traits leading to a “master of all traits”. The shape of trade-offs has been shown to …

Intra-tumor heterogeneity (ITH) is a major underlying cause of therapy resistance and disease
recurrence, and is a read-out of tumor growth. Current genetic ITH analysis methods do …

Both normal tissue development and cancer growth are driven by a branching process of
cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. …

Carbamazepine (CBZ) and its metabolite carbamazepine-10,11-epoxide (CBZEP) play vital
role in the treatment of epilepsy. It is of great importance to develop a method for rapid and …

Under neutrality, polymorphisms are maintained through the balance between mutation and
drift. Under selection, a variety of mechanisms may be involved in the maintenance of …

Background & Aims Barrett’s esophagus (BE) is a risk factor for esophageal adenocarcinoma
but our understanding of how it evolves is poorly understood. We investigated BE gland …

The signature of early cancer dynamics on the spatial arrangement of tumour cells is poorly
understood, and yet could encode information about how sub-clones grew within the …