Role of nitric oxide in the regulation of oxygen consumption in conscious dogs.

W Shen, X Xu, M Ochoa, G Zhao, MS Wolin… - Circulation …, 1994 - Am Heart Assoc
The role of nitric oxide (NO) in the regulation of O2 consumption was studied in chronically
instrumented conscious dogs. A specific NO synthesis inhibitor, nitro-L-arginine (NLA, 30 mg/…

Progressive loss of myocardial ATP due to a loss of total purines during the development of heart failure in dogs: a compensatory role for the parallel loss of creatine

W Shen, K Asai, M Uechi, MA Mathier, RP Shannon… - Circulation, 1999 - Am Heart Assoc
Background—Whether myocardial ATP content falls in heart failure is a long-standing and
controversial issue. The mechanism(s) to explain any decrease in ATP content during heart …

Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise.

W Shen, X Zhang, G Zhao, MS Wolin… - Medicine and science …, 1995 - europepmc.org
Nitric oxide production and NO synthase gene expression contribute to vascular regulation
during exercise. - Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe …

Nitric oxide: an important signaling mechanism between vascular endothelium and parenchymal cells in the regulation of oxygen consumption

W Shen, TH Hintze, MS Wolin - Circulation, 1995 - Am Heart Assoc
Background Nitric oxide (NO) is known to be an inhibitor of mitochondrial function. However,
the physiological significance of endothelium-derived NO in the control of tissue respiration …

Solution Structure of Human Brg1 Bromodomain and Its Specific Binding to Acetylated Histone Tails,

W Shen, C Xu, W Huang, J Zhang, JE Carlson, X Tu… - Biochemistry, 2007 - ACS Publications
Human brahma-related gene 1 (Brg1) is a core protein in human SWI/SNF chromatin-remodeling
complex which regulates gene expression. Brg1 contains a bromodomain that has …

Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs

…, CI Thompson, PR Forfia, N Seyedi, W Shen… - Circulation, 1995 - Am Heart Assoc
Background The present investigation was undertaken to better understand the production
of nitric oxide (NO) in vivo as measured by alterations in plasma nitrite or nitrate in blood …

Role of endothelium-derived nitric oxide in the modulation of canine myocardial mitochondrial respiration in vitro: implications for the development of heart failure

YW Xie, W Shen, G Zhao, X Xu, MS Wolin… - Circulation …, 1996 - Am Heart Assoc
The mechanism responsible for the regulation of cardiac function by endogenous nitric oxide
(NO) remains unclear. In this investigation, O 2 consumption by freshly isolated myocardial …

Function and production of nitric oxide in the coronary circulation of the conscious dog during exercise

…, FY Ochoa, X Xu, P Forfia, W Shen… - Circulation …, 1996 - Am Heart Assoc
This study determined the changes in NO production from the coronary circulation of the
conscious dog during exercise. The role of endogenous NO as it relates to coronary flow, …

[HTML][HTML] Kinetic, thermodynamic, and developmental consequences of deleting creatine kinase isoenzymes from the heart: reaction kinetics of the creatine kinase …

KW Saupe, M Spindler, JCA Hopkins, W Shen… - Journal of Biological …, 2000 - ASBMB
Creatine kinase (CK) exists as a family of isoenzymes in excitable tissue. We studied
isolated perfused hearts from mice lacking genes for either the main muscle isoform of CK (M-CK) …

ALCAT1 is a polyglycerophospholipid acyltransferase potently regulated by adenine nucleotide and thyroid status

J Cao, W Shen, Z Chang, Y Shi - American Journal of …, 2009 - journals.physiology.org
Acyl-CoA:lysocardiolipin acyltransferase-1 (ALCAT1) catalyzes acylation of lysocardiolipin
back to cardiolipin, an important step in cardiolipin remodeling. The present study reports the …