User profiles for Weizhong Zeng
 | Weizhong ZengUTSW Verified email at utsouthwestern.edu Cited by 9474 |
SOAR and the polybasic STIM1 domains gate and regulate Orai channels
Influx of Ca 2+ through store-operated Ca 2+ channels (SOCs) is a central component of
receptor-evoked Ca 2+ signals 1 . Orai channels are SOCs 2 , 3 , 4 that are gated by STIM1, a …
receptor-evoked Ca 2+ signals 1 . Orai channels are SOCs 2 , 3 , 4 that are gated by STIM1, a …
STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels
Receptor-evoked Ca 2+ signalling involves Ca 2+ release from the endoplasmic reticulum,
followed by Ca 2+ influx across the plasma membrane 1 . Ca 2+ influx is essential for many …
followed by Ca 2+ influx across the plasma membrane 1 . Ca 2+ influx is essential for many …
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels
Stromal interacting molecule 1 (STIM1) is a Ca 2+ sensor that conveys the Ca 2+ load of the
endoplasmic reticulum to store-operated channels (SOCs) at the plasma membrane. Here, …
endoplasmic reticulum to store-operated channels (SOCs) at the plasma membrane. Here, …
Gating of CFTR by the STAS domain of SLC26 transporters
Chloride absorption and bicarbonate secretion are vital functions of epithelia 1 , 2 , 3 , 4 , 5 ,
6 , as highlighted by cystic fibrosis and diseases associated with mutations in members of …
6 , as highlighted by cystic fibrosis and diseases associated with mutations in members of …
[PDF][PDF] STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction
W Zeng, JP Yuan, MS Kim, YJ Choi, GN Huang… - Molecular cell, 2008 - cell.com
The receptor-evoked Ca 2+ signal includes activation of the store-operated channels (SOCs)
TRPCs and the Orais. Although both are gated by STIM1, it is not known how STIM1 gates …
TRPCs and the Orais. Although both are gated by STIM1, it is not known how STIM1 gates …
Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger
Sodium/calcium (Na + /Ca 2+ ) exchangers (NCX) are membrane transporters that play an
essential role in maintaining the homeostasis of cytosolic Ca 2+ for cell signaling. We …
essential role in maintaining the homeostasis of cytosolic Ca 2+ for cell signaling. We …
Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana
Two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM)
domain in each subunit and are ubiquitously expressed in both animals and plants as …
domain in each subunit and are ubiquitously expressed in both animals and plants as …
TRPC channels as STIM1-regulated store-operated channels
Receptor-activated Ca 2+ influx is mediated largely by store-operated channels (SOCs).
TRPC channels mediate a significant portion of the receptor-activated Ca 2+ influx. However, …
TRPC channels mediate a significant portion of the receptor-activated Ca 2+ influx. However, …
[HTML][HTML] Polarized expression of Ca2+ channels in pancreatic and salivary gland cells: correlation with initiation and propagation of [Ca2+] i waves
In polarized epithelial cells [Ca 2+ ] i waves are initiated in discrete regions and propagate
through the cytosol. The structural basis for these compartmentalized and coordinated events …
through the cytosol. The structural basis for these compartmentalized and coordinated events …
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
Transient receptor potential mucolipin 1 (TRPML1) is a cation channel located within endosomal
and lysosomal membranes. Ubiquitously expressed in mammalian cells 1 , 2 , its loss-of…
and lysosomal membranes. Ubiquitously expressed in mammalian cells 1 , 2 , its loss-of…