Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against
the coronavirus spike glycoprotein will provide crucial advances towards the development of …

Germinal centres are the engines of antibody evolution. Here, using human immunodeficiency
virus (HIV) Env protein immunogen priming in rhesus monkeys followed by a long period …

Pancreatic cancer has an extremely high mortality rate due to its aggressive metastatic nature.
Resolving the underlying mechanisms will be crucial for treatment. Here, we found that …

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by
binding of the viral Spike protein to host receptor angiotensin-converting enzyme 2 (ACE2), …

Metastasis is a significant health issue. The standard mode of care is combination of
chemotherapy and targeted therapeutics but the 5-year survival rate remains low. New/better drug …

10.7554/eLife.38461.001 SWELL1 (LRRC8A) is the only essential subunit of the Volume
Regulated Anion Channel (VRAC), which regulates cellular volume homeostasis and is …

Hepatitis C virus (HCV) infection affects approximately 58 million people and causes ~300,000
deaths yearly. The only target for HCV neutralizing antibodies is the highly sequence …

The immune responses and mechanisms limiting symptom progression in asymptomatic
cases of SARS‐CoV‐2 infection remain unclear. We comprehensively characterized …

The aims of the present study were to determine the antibacterial activity of bark extract of
Cryptomeria japonica D. Don and to isolate potential antibacterial constituents. The results …

The generation of high-quality antibody responses to Plasmodium falciparum (Pf) circumsporozoite
protein (PfCSP), the primary surface antigen of Pf sporozoites, is paramount to the …