To improve clinical outcomes for CAR T-cell therapy, there is a need to understand the
molecular determinants of CAR T-cell persistence. These data represent the largest clinically …

Hematopoietic stem and progenitor cells (HSPCs) in the bone marrow are derived from a
small population of hemogenic endothelial (HE) cells located in the major arteries of the …

KMT2A-rearranged (KMT2A-r) infant acute lymphoblastic leukemia (ALL) is a devastating
malignancy with a dismal outcome, and younger age at diagnosis is associated with increased …

The spatial organization of the genome plays a critical role in regulating gene expression.
Recent chromatin interaction mapping studies have revealed that topologically associating …

Fetal hematopoietic stem cells (HSCs) undergo a developmental switch to become adult
HSCs with distinct functional properties. To better understand the molecular mechanisms …

Single-cell chromatin accessibility sequencing has become a powerful technology for
understanding epigenetic heterogeneity of complex tissues. However, there is a lack of open-…

The transcription factor RUNX1 is mutated in familial platelet disorder with associated myeloid
malignancy (FPDMM) and in sporadic myelodysplastic syndrome and leukemia. RUNX1 …

Motivation Gene–gene interaction (GGI) is one of the most popular approaches for finding
and explaining the missing heritability of common complex traits in genome-wide association …

Factors responsible for undesirable coagulation performance in winter have not been well
understood by far. The aim of this work is to identify the critical factor(s) and to provide …

Objectives: To determine gene-gene interactions and missing heritability of complex diseases
is a challenging topic in genome-wide association studies. The multifactor dimensionality …