The release and nuclear translocation of the intracellular domain of Notch receptor (NICD)
is the prerequisite for Notch signaling-mediated transcriptional activation. NICD is subjected …

… Wenchen Shen and Huilong Yu validated the hybrid electric powertrain model, implemented
the proposed strategy and wrote the paper together, they contributed equally in this work; …

The mechanisms underlying spatial and temporal control of cortical neurogenesis of the brain
are largely elusive. Long non-coding RNAs (lncRNAs) have emerged as essential cell fate …

In utero electroporation (IUE) is commonly used to study cortical development of cerebrum
by downregulating or overexpressing genes of interest in neural progenitor cells (NPCs) of …

Long non-coding RNAs (lncRNAs) regulate transcription to control development and
homeostasis in a variety of tissues and organs. However, their roles in the development of the …

The hippocampus plays major roles in learning and memory, and its formation requires
precise coordination of patterning, cell proliferation, differentiation, and migration. Here we …

Lentiviral vector (LVV) has been used as one of the common carriers for gene therapy in
clinical trials. LVV-mediated clinical trials have being reported in successfully treating hundreds …

Background LentiGlobin BB305 is a self‐inactivating lentiviral vector carrying a human β‐globin
expressing cassette for treating β‐thalassemia. Initially, a 2 × 250 bp chicken Locus …

Fault detection and diagnosis strategy based on AMT (Automatic Mechanical Transmission)
system trajectory is studied. Hybrid automata is used to build healthy AMT system model. …

Glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) plays a critical role in cancer
metabolism by coordinating glycolysis and biosynthesis. A well-validated PGAM1 inhibitor, …