The molecular mechanisms underlying atrial fibrillation, the most common sustained cardiac
arrhythmia, remain poorly understood. Genome-wide association studies uncovered a …

In humans, atrial fibrillation is often triggered by ectopic pacemaking activity in the myocardium
sleeves of the pulmonary vein (PV) and systemic venous return. The genetic programs …

… We dedicate this work to the memory of Wenduo Ye, an exceptional colleague and caring
friend who generated data for this study. We thank Jose Cabrera for graphics, John McAnally …

Direct reprogramming of fibroblasts to cardiomyocytes represents a potential means of
restoring cardiac function following myocardial injury. AKT1 in the presence of four cardiogenic …

The cardiogenic transcription factors (TFs) Mef2c, Gata4, and Tbx5 can directly reprogram
fibroblasts to induced cardiac-like myocytes (iCLMs), presenting a potential source of cells for …

The definitive sinoatrial node (SAN), the primary pacemaker of the mammalian heart, develops
from part of pro-pacemaking embryonic venous pole that expresses both Hcn4 and the …

The central importance of BMP signaling in the development and homeostasis of synovial
joint of appendicular skeleton has been well documented, but its role in the development of …

Odontoblasts and osteoblasts develop from multipotent craniofacial neural crest cells during
tooth and jawbone development, but the mechanisms that specify and sustain their …

The atrioventricular (AV) junction plays a critical role in chamber septation and transmission
of cardiac conduction pulses. It consists of structures that develop from embryonic dorsal …

Homeodomain proteins are crucial transcription factors for cell differentiation, cell proliferation
and organ development. Interestingly, their homeodomain signature structure is important …