Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on
genomic alterations but have rarely considered the biological properties of plasma cell-free …

METHODS AND RESULTS We reviewed the notes of 149 BWS patients who had been
referred to the BWS Research Group at the Birmingham University Section of Medical Genetics …

The 2021 WHO Classification of Thoracic Tumours was published earlier this year, with
classification of lung tumors being one of the chapters. The principles remain those of using …

Background TargomiRs are minicells (EnGeneIC Dream Vectors) loaded with miR-16-based
mimic microRNA (miRNA) and targeted to EGFR that are designed to counteract the loss of …

In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been growing. …

The tomato ACC oxidase gene family is comprised of three members designated ACO1,
ACO2 and ACO3. These are highly homologous throughout the protein coding regions but do …

A malignant tumor is not merely an accumulation of neoplastic cells, but constitutes a
microenvironment containing endothelial cells, fibroblasts, structural components, and infiltrating …

Lung cancers are characterised by abundant genetic diversity with relatively few recurrent
mutations occurring at high frequency. However, the genetic alterations often affect a common …

Importance Checkpoint inhibitors have replaced docetaxel as the new standard second-line
therapy in advanced non–small cell lung carcinoma (NSCLC), but little is known about the …

Introduction A grading system for pulmonary adenocarcinoma has not been established. The
International Association for the Study of Lung Cancer pathology panel evaluated a set of …