User profiles for Wendy Thomson
 | Wendy ThomsonProfessor of Genetic Epidemiology, University of Manchester Verified email at manchester.ac.uk Cited by 36187 |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
…, EF Remmers, G Xie, S Eyre, BP Thomson… - Nature …, 2010 - nature.com
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …
Meta-analysis and imputation refines the association of 15q25 with smoking quantity
…, M Farrall, A Dominiczak, J Worthington, W Thomson… - Nature …, 2010 - nature.com
Smoking is a leading global cause of disease and mortality 1 . We established the Oxford-GlaxoSmithKline
study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association …
study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association …
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
…, C Potter, AJ Silman, DPM Symmons, W Thomson… - Nature, 2007 - nature.com
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …
to more common diseases than any other region of the human genome, including almost …
Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: Further support that PTPN22 is an autoimmunity …
…, CEM Griffiths, R Donn, W Thomson… - Arthritis & …, 2005 - Wiley Online Library
Objective The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities
for both T cells and B cells. A missense single‐nucleotide polymorphism (SNP) within this …
for both T cells and B cells. A missense single‐nucleotide polymorphism (SNP) within this …
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
…, JP Haas, DN Glass, CD Langefeld, W Thomson… - Nature …, 2013 - nature.com
We used the Immunochip array to analyze 2,816 individuals with juvenile idiopathic arthritis
(JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor–negative …
(JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor–negative …
Rheumatoid arthritis association at 6q23
W Thomson, A Barton, X Ke, S Eyre, A Hinks, J Bowes… - Nature …, 2007 - nature.com
The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs
putatively associated with rheumatoid arthritis at P = 1 × 10 −5 − 5 × 10 −7 in a genome-wide …
putatively associated with rheumatoid arthritis at P = 1 × 10 −5 − 5 × 10 −7 in a genome-wide …
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
S Raychaudhuri, BP Thomson, EF Remmers, S Eyre… - Nature …, 2009 - nature.com
To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs
from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide …
from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide …
Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor …
…, WER Ollier, W Thomson… - Arthritis & …, 2002 - Wiley Online Library
Objective To determine if polymorphisms of the macrophage migration inhibitory factor (MIF)
gene are associated with juvenile idiopathic arthritis (JIA). Methods Denaturing high‐…
gene are associated with juvenile idiopathic arthritis (JIA). Methods Denaturing high‐…
Quantitative heritability of anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis
Objective The majority of genetic risk factors for rheumatoid arthritis (RA) are associated with
anti–citrullinated protein antibody (ACPA)–positive RA, while far fewer genetic risk factors …
anti–citrullinated protein antibody (ACPA)–positive RA, while far fewer genetic risk factors …
Association of the HLA–DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis
Objective To examine the role of the variants of the PTPN22 and HLA–DRB1 genes as
predictors of mortality in inflammatory polyarthritis (IP) and rheumatoid arthritis (RA). Methods …
predictors of mortality in inflammatory polyarthritis (IP) and rheumatoid arthritis (RA). Methods …