Throughout our lifespan, new sensory experiences and learning continually shape our
neuronal circuits to form new memories. Plasticity at the level of synapses has been recognized …

In recent years, the role of astrocytes in shaping neuronal signaling has come to the
forefront of neuroscience research. The development of genetic tools that enable targeted …

Severe cognitive decline is a hallmark of Alzheimer's disease (AD). In addition to gray
matter loss, significant white matter pathology has been identified in AD patients. Here, we …

Many biomarkers in clinical neuroscience lack pathological certification. This issue is potentially
a significant contributor to the limited success of neuroprotective and neurorestorative …

Glutamate has been implicated in a wide range of brain pathologies and is thought to be
metabolized via the astrocyte-specific enzyme glutamine synthetase (GS). We show here that …

Astrocytes are ubiquitous CNS cells that support tissue homeostasis through ion buffering,
neurotransmitter recycling, and regulation of CNS vasculature. Yet, despite the essential …

Electrical or optogenetic stimulation of lateral hypothalamic (LH) GABA neurons induces
rapid vigorous eating in sated animals. The dopamine system has been implicated in the …

TDP-43 is extensively studied in neurons in physiological and pathological contexts.
However, emerging evidence indicates that glial cells are also reliant on TDP-43 function. We …

Dopamine neurons in the ventral tegmental area (VTA) are involved in a variety of
physiological and pathological conditions, ranging from motivated behaviours to substance use …

Learning requires new oligodendrogenesis, but how myelin patterns change during learning
is unclear. Bacmeister et al. show that motor learning induces phase-specific changes in …