Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal
end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia …

Subdistal appendages (sDAPs) are centriolar elements that are observed proximal to the
distal appendages (DAPs) in vertebrates. Despite the obvious presence of sDAPs, structural …

We report a patient who presented with congenital hypotonia, hypoventilation, and cerebellar
histopathological alterations. Exome analysis revealed a homozygous mutation in the …

Primary cilia are sensory organelles present on most vertebrate cells and are critical for
development and health. Ciliary dysfunction is associated with a large class of human …

Primary cilia play a vital role in cellular sensing and signaling. An essential component of
ciliogenesis is intraflagellar transport (IFT), which is involved in IFT protein recruitment, …

The non-structural protein 5A (NS5A) is a hepatitis C virus (HCV) protein indispensable for
the viral life cycle. Many prior papers have pinpointed several serine residues in the low …

Centrin 2 is a small conserved calcium-binding protein that localizes to the centriolar distal
lumen in human cells. It is required for efficient primary ciliogenesis and nucleotide excision …

Protein phosphorylation is a reversible post-translational modification that regulates many
biological processes in almost all living forms. In the case of the hepatitis C virus (HCV), the …

The characteristic lengths of molecular arrangement in primary cilia are below the diffraction
limit of light, challenging structural and functional studies of ciliary proteins. Superresolution …

Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal
end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia …