Advances in biological and medical technologies have been providing us explosive volumes
of biological and physiological data, such as medical images, electroencephalography, …

Chromatin insulators are DNA elements that regulate the level of gene expression either by
preventing gene silencing through the maintenance of heterochromatin boundaries or by …

Motivation Enhancer elements are noncoding stretches of DNA that play key roles in
controlling gene expression programmes. Despite major efforts to develop accurate enhancer …

Maternal obesity can impair embryo development and offspring health, yet the mechanisms
responsible remain poorly understood. In a high-fat diet (HFD)-based female mouse model …

Transcriptional enhancers are non-coding segments of DNA that play a central role in the
spatiotemporal regulation of gene expression programs. However, systematically and …

N 6 -methyladenosine (m 6 A) is the most prevalent epigenetic modification of messenger
RNA (mRNA) in higher eukaryotes; this modification is mainly catalyzed by a …

KIAA1429 (also known as vir-like m 6 A methyltransferase-associated protein (VIRMA)), a
newly identified component of the RNA m 6 A methyltransferase complex, plays critical roles in …

Well-balanced and timed metabolism is essential for making a high-quality egg. However,
the metabolic framework that supports oocyte development remains poorly understood. Here, …

Polo-like kinase 1 (Plk1) is a crucial regulator of cell cycle progression; but the mechanism
of regulation of Plk1 activity is not well understood. We present evidence that Plk1 activity is …

Motivation: The de novo identification of the initiation and termination zones—regions that
replicate earlier or later than their upstream and downstream neighbours, respectively—…