User profiles for Wenpin Hou
 | Wenpin Hou, Ph.D.Assistant Professor, Department of Biostatistics, Columbia University Verified email at cumc.columbia.edu Cited by 887 |
[HTML][HTML] A systematic evaluation of single-cell RNA-sequencing imputation methods
Background The rapid development of single-cell RNA-sequencing (scRNA-seq) technologies
has led to the emergence of many methods for removing systematic technical noises, …
has led to the emergence of many methods for removing systematic technical noises, …
[HTML][HTML] Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers
PD-1 blockade unleashes CD8 T cells 1 , including those specific for mutation-associated
neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell …
neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell …
Association of cord plasma biomarkers of in utero acetaminophen exposure with risk of attention-deficit/hyperactivity disorder and autism spectrum disorder in …
Importance Prior studies have raised concern about maternal acetaminophen use during
pregnancy and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism …
pregnancy and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism …
[HTML][HTML] Assessing GPT-4 for cell type annotation in single-cell RNA-seq analysis
Here we demonstrate that the large language model GPT-4 can accurately annotate cell types
using marker gene information in single-cell RNA sequencing analysis. When evaluated …
using marker gene information in single-cell RNA sequencing analysis. When evaluated …
[HTML][HTML] DNA methylation mediates the effect of maternal smoking on offspring birthweight: a birth cohort study of multi-ethnic US mother–newborn pairs
Background Maternal smoking affects more than half a million pregnancies each year in the
US and is known to result in fetal growth restriction as measured by lower birthweight and its …
US and is known to result in fetal growth restriction as measured by lower birthweight and its …
Lung tumor–infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response
Regulatory T cells (T reg ) are conventionally viewed as suppressors of endogenous and
therapy-induced antitumor immunity; however, their role in modulating responses to immune …
therapy-induced antitumor immunity; however, their role in modulating responses to immune …
[HTML][HTML] GeneSegNet: a deep learning framework for cell segmentation by integrating gene expression and imaging
When analyzing data from in situ RNA detection technologies, cell segmentation is an essential
step in identifying cell boundaries, assigning RNA reads to cells, and studying the gene …
step in identifying cell boundaries, assigning RNA reads to cells, and studying the gene …
[HTML][HTML] GeneTuring tests GPT models in genomics
Generative Pre-trained Transformers (GPT) are powerful language models that have great
potential to transform biomedical research. However, they are known to suffer from artificial …
potential to transform biomedical research. However, they are known to suffer from artificial …
[HTML][HTML] Single-cell ATAC-seq signal extraction and enhancement with SCATE
Single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq) is the
state-of-the-art technology for analyzing genome-wide regulatory landscapes in single cells. …
state-of-the-art technology for analyzing genome-wide regulatory landscapes in single cells. …
In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals
Background/Objectives Low-level, in-utero exposure to toxic metals such as lead (Pb) and
mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be …
mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be …