The actin cytoskeleton is a dynamic cellular network known for its function in cell morphology
and motility. Recent studies using high resolution and real time imaging techniques have …

A major function of the B cell is the internalization of antigen through the BCR for processing
and presentation to T cells. While there is evidence suggesting that lipid raft signaling may …

Patients with the immunodeficiency Wiskott-Aldrich syndrome (WAS) frequently develop
systemic autoimmunity. Here, we demonstrate that mutation of the WAS gene results in B cells …

10.7554/eLife.00926.001 Rapid repair of plasma membrane wounds is critical for cellular
survival. Muscle fibers are particularly susceptible to injury, and defective sarcolemma …

The high efficiency of Ag processing and presentation by B cells requires Ag-induced BCR
signaling and actin cytoskeleton reorganization, although the underlying mechanism for such …

Campylobacter jejuni and Campylobacter coli colonize and infect the intestinal epithelium
and cause acute inflammatory diarrhea. The intestinal epithelium serves as a physical barrier …

The cross-linking of the B cell Ag receptor (BCR) leads to the initiation of a signal transduction
cascade in which the earliest events involve the phosphorylation of the immunoreceptor …

Upon recognizing cognate antigen, B cells mobilize multiple cellular apparatuses to propagate
an optimal response. Antigen binding is transduced into cytoplasmic signaling events …

Lipooligosaccharide (LOS) has been implicated in the adhesion and invasion of host epithelial
cells. We examined the adhesive and invasive abilities of isogenic gonococcal opacity-…

Negative regulation of receptor signaling is essential for controlling cell activation and
differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) signaling is …