A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally
detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission leads to the
emergence of variants, including the B.1.617.2 (Delta) variant of concern that is causing a …

Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000
deaths per year worldwide. Vaccine development has proved difficult and resistance has …

A new drug screening method was devised utilizing Trypanosoma cruzi cells that express
the Escherichia coli beta-galactosidase gene. Transfected parasites catalyze a colorimetric …

Despite substantial scientific progress over the past two decades, malaria remains a worldwide
burden that causes hundreds of thousands of deaths every year. New, affordable and …

Characterizing SARS-CoV-2 evolution in specific geographies may help predict properties
of the variants that come from these regions. We mapped neutralization of a SARS-CoV-2 …

We have obtained four monoclonal antibodies, IB4, OKM1, OKM9, and OKM10, all directed
against the C3bi receptor of human monocytes and macrophages (M phi). Two criteria were …

Previous studies demonstrated that lymphoid tissues of mice and rats contain small numbers
(less than 1 percent of nucleated cells) of dendritic cells (DC) with special cytologic, surface…

The increasing availability of genomic data for pathogens that cause tropical diseases has
created new opportunities for drug discovery and development. However, if the potential of …

A major cause of the paucity of new starting points for drug discovery is the lack of interaction
between academia and industry. Much of the global resource in biology is present in …