Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective
…, K Römermann, P Hampel, B Gailus, W Theilmann… - …, 2021 - Wiley Online Library
Objective Neonatal seizures are the most frequent type of neurological emergency in newborn
infants, often being a consequence of prolonged perinatal asphyxia. Phenobarbital is …
infants, often being a consequence of prolonged perinatal asphyxia. Phenobarbital is …
[HTML][HTML] Cortical excitability and activation of TrkB signaling during rebound slow oscillations are critical for rapid antidepressant responses
S Kohtala, W Theilmann, M Rosenholm, L Penna… - Molecular …, 2019 - Springer
Rapid antidepressant effects of ketamine become most evident when its psychotomimetic
effects subside, but the neurobiological basis of this “lag” remains unclear. Laughing gas (N 2 …
effects subside, but the neurobiological basis of this “lag” remains unclear. Laughing gas (N 2 …
[HTML][HTML] P11 promoter methylation predicts the antidepressant effect of electroconvulsive therapy
A Neyazi, W Theilmann, C Brandt, T Rantamäki… - Translational …, 2018 - nature.com
Although electroconvulsive therapy (ECT) is among the most effective treatment options for
pharmacoresistant major depressive disorder (MDD), some patients still remain refractory to …
pharmacoresistant major depressive disorder (MDD), some patients still remain refractory to …
Behavioral differences of male Wistar rats from different vendors in vulnerability and resilience to chronic mild stress are reflected in epigenetic regulation and …
W Theilmann, A Kleimann, M Rhein, S Bleich… - Brain Research, 2016 - Elsevier
Outbred rat lines such as Wistar rats are commonly used for models of depressive disorders.
Such rats arise from random mating schedules. Hence, genetic drift occurs in outbred …
Such rats arise from random mating schedules. Hence, genetic drift occurs in outbred …
Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis …
W Theilmann, B Gericke, A Schidlitzki, SMM Anjum… - …, 2020 - Elsevier
Mechanistic target of rapamycin (mTOR) regulates cell proliferation, growth and survival,
and is activated in cancer and neurological disorders, including epilepsy. The rapamycin …
and is activated in cancer and neurological disorders, including epilepsy. The rapamycin …
Brief isoflurane anesthesia produces prominent phosphoproteomic changes in the adult mouse hippocampus
Anesthetics are widely used in medical practice and experimental research, yet the
neurobiological basis governing their effects remains obscure. We have here used quantitative …
neurobiological basis governing their effects remains obscure. We have here used quantitative …
[HTML][HTML] Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine …
S Kohtala, W Theilmann, M Rosenholm, HK Müller… - …, 2019 - Elsevier
Subanesthetic rather than anesthetic doses are thought to bring the rapid antidepressant
effects of the NMDAR (N-methyl-d-aspartate receptor) antagonist ketamine. Among molecular …
effects of the NMDAR (N-methyl-d-aspartate receptor) antagonist ketamine. Among molecular …
Brief isoflurane anesthesia regulates striatal AKT‐GSK3β signaling and ameliorates motor deficits in a rat model of early‐stage Parkinson′ s disease
JV Leikas, S Kohtala, W Theilmann… - Journal of …, 2017 - Wiley Online Library
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder primarily
affecting the nigrostriatal dopaminergic system. The link between heightened activity of …
affecting the nigrostriatal dopaminergic system. The link between heightened activity of …
[HTML][HTML] Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe …
…, A Schidlitzki, B Gericke, K Töllner, W Theilmann… - Neurobiology of …, 2021 - Elsevier
Increased neuronal expression of the Na-K-2Cl cotransporter NKCC1 has been implicated in
the generation of seizures and epilepsy. However, conclusions from studies on the NKCC1-…
the generation of seizures and epilepsy. However, conclusions from studies on the NKCC1-…
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent …
Chemically or electrically induced status epilepticus (SE) in rodents is a commonly used
method for induction of epilepsy. Structural and functional changes in the hippocampus play a …
method for induction of epilepsy. Structural and functional changes in the hippocampus play a …