Insulin provides a classical model of a globular protein, yet how the hormone changes
conformation to engage its receptor has long been enigmatic. Interest has focused on the C-…

The voltage-dependent motor protein prestin (also known as SLC26A5) is responsible for
the electromotive behaviour of outer-hair cells and underlies the cochlear amplifier 1 . …

“Derivative isolates” with 4- to 8-fold and 8- to 16-fold increases in MICs of vancomycin and
teicoplanin, respectively, were selected from 2 susceptible clinical isolates of Staphylococcus …

The voltage-gated proton channel Hv1 plays a critical role in the fast proton translocation that
underlies a wide range of physiological functions, including the phagocytic respiratory burst…

Insulin-like growth factor I (IGF-I) is required for normal embryonic development and postnatal
growth. Like most hormones and growth factors, IGF-I is synthesized as a proprotein that is …

Diabetes (T1DM and T2DM) is characterized by a deficit in β-cell mass. A broader understanding
of human β-cell replication mechanism is thus important to increase β-cell proliferation …

We previously reported the isolation of a laboratory-derived Staphylococcus aureus mutant,
523k, that has constitutive low-level resistance to vancomycin (MIC = 5 micrograms/ml) and …

Adult human pancreatic β-cells are primarily quiescent (G0) yet the mechanisms controlling
their quiescence are poorly understood. Here, we demonstrate, by immunofluorescence and …

The voltage-dependent motor protein, Prestin (SLC26A5) is responsible for the electromotive
behavior of outer hair cells (OHCs). Here, we determined the structure of dolphin Prestin in …

Insulin-secreting pancreatic beta cells play a key role in the pathogenesis of diabetes
mellitus. Potential new treatments for this disease include cell-replacement therapies using …