Expression of HPV16 early region genes in basal keratinocytes of transgenic mice elicits a
multistage pathway to squamous carcinoma. We report that infiltration by mast cells and …

BACKGROUND. The link between mucus plugs and airflow obstruction has not been established
in chronic severe asthma, and the role of eosinophils and their products in mucus plug …

Mast cells secrete α- and β-chymases. Primate α-chymases generate angiotensin (AT) II by
selectively hydrolyzing AT I’s Phe 8 –His 9 bond. This is distinct from the AT converting …

Rationale: Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are
implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL-1β …

Rationale: Airway mucus plugs, composed of mucin glycoproteins mixed with plasma proteins,
are an important cause of airway obstruction in acute severe asthma, and they are poorly …

In prior work we showed that a metallogelatinase is secreted from dog mastocytoma cells
and directly activated by exocytosed mast cell α-chymase. The current work identifies the …

Previously, this laboratory identified clusters of α-, β-, and mast cell protease-7-like tryptase
genes on human chromosome 16p13. 3. The present work characterizes adjacent genes …

Gelatinolytic metalloproteinases implicated in connective tissue remodeling and tumor
invasion are secreted from several types of cells in the form of inactive zymogens. In this report, …

Background Mucin disulfide cross-links mediate pathologic mucus formation in muco-obstructive
lung diseases. MUC-031, a novel thiol-modified carbohydrate compound, cleaves …

Allergic asthma is the most common form of asthma, affecting more than 10 million Americans.
Although it is clear that mast cells have a key role in the pathogenesis of allergic asthma, …