THE low-density-lipoprotein (LDL) receptor is a cell-surface pro-tein that plays an important
part in the metabolism of cholesterol by mediating the uptake of LDL from plasma into cells 1 …

Noncoding small RNAs, such as microRNAs, are becoming the biomarkers of choice for
multiple diseases in clinical diagnostics. A dysregulation of these microRNAs can be associated …

In multicellular systems cell identity is imprinted by epigenetic regulation circuits, which
determine the global transcriptome of adult cells in a cell phenotype–specific manner 1 , 2 , 3 . By …

Synthetic biology aims to create functional devices, systems and organisms with novel and
useful functions on the basis of catalogued and standardized biological building blocks. …

Interrogation and control of cellular fate and function using optogenetics is providing revolutionary
insights into biology. Optogenetic control of cells is achieved by coupling genetically …

Drug-dependent dissociation or association of cellular receptors represents a potent
pharmacologic mode of action for regulating cell fate and function 1 , 2 . Transferring the knowledge …

The polymorphism of apolipoprotein E (Apo E) in man is controlled by two codominant
alleles, Apo E n and Apo E d, at the Apo EN/D locus and by two alleles, the dominant, Apo …

Heterologous mammalian gene regulation systems for adjustable expression of multiple
transgenes are necessary for advanced human gene therapy and tissue engineering, and for …

Optogenetics is the genetic approach for controlling cellular processes with light. It provides
spatiotemporal, quantitative and reversible control over biological signaling and metabolic …

Recent far-reaching advances in synthetic biology have yielded exciting tools for the
creation of new materials. Conversely, advances in the fundamental understanding of soft-…