We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…

Over 11 million Americans have both diabetes and hypertension—comorbid diseases that
strongly predispose people to both renal as well as cardiovascular (CV) injury. Hypertension …

Adipose tissue is a dynamic endocrine organ that secretes a number of factors that are
increasingly recognized to contribute to systemic and vascular inflammation. Several of these …

Background—Peroxisome proliferator–activated receptor-γ (PPARγ) is activated by fatty
acids, eicosanoids, and insulin-sensitizing thiazolidinediones (TZDs). The TZD troglitazone (…

The nuclear receptors LXRα and LXRβ have been implicated in the control of cholesterol
and fatty acid metabolism in multiple cell types. Activation of these receptors stimulates …

Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions, including
cancer, and is increasingly recognized as a growing cause of preventable cancer risk. …

Background—Angiotensin II (Ang II) is implicated in cardiac remodeling and is increasingly
recognized for its profibrotic activity. Methods and Results—Because little is known about the …

Vascular smooth muscle cell (VSMC) proliferation and migration are responses to arterial
injury that are highly important to the processes of restenosis and atherosclerosis. In the …

The endothelium regulates vascular tone through the release of vasodilating and vasoconstricting
substances. The most important of these vasodilating substances is nitric oxide (NO), …

Adipose-resident T cells (ARTs) regulate metabolic and inflammatory responses in obesity,
but ART activation signals are poorly understood. Here, we describe class II major …