Highlights • The human gut microbiome harbours antibiotic resistance genes (‘the resistome’).
• Antibiotic resistance genes can spread in the gut microbiome through horizontal gene …

In recent decades, the emergence and spread of antibiotic resistance among bacterial
pathogens has become a major threat to public health. Bacteria can acquire antibiotic resistance …

Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have
pronounced effects on gut microbiome development and selection of antimicrobial resistance …

Outbreaks of multidrug-resistant bacteria present a frequent threat to vulnerable patient
populations in hospitals around the world. Intensive care unit (ICU) patients are particularly …

Enterococci are Gram-positive bacteria that are found in plants, soil and as commensals of
the gastrointestinal tract of humans, mammals, and insects. Despite their commensal nature, …

Enterococcus faecium , natively a gut commensal organism, emerged as a leading cause of
multidrug-resistant hospital-acquired infection in the 1980s. As the living record of its …

The enterococci evolved over eons as highly adapted members of gastrointestinal consortia
of a wide variety of hosts, but for reasons that are not entirely clear, emerged in the 1970s as …

Previous studies have shown high acquisition risks of extended-spectrum beta-lactamase-producing
Enterobacteriaceae (ESBL-E) among international travelers visiting antimicrobial …

Antibiotic resistance genes are found in a broad range of ecological niches associated with
complex microbiota. Here we investigated if resistance genes are not only present, but also …

Third-generation cephalosporins are a class of β-lactam antibiotics that are often used for
the treatment of human infections caused by Gram-negative bacteria, especially Escherichia …