[HTML][HTML] Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with
high mortality, uncertain cause, and few treatment options. Studies have identified a significant …
high mortality, uncertain cause, and few treatment options. Studies have identified a significant …
Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis
…, P Sakornsakolpat, HL Booth, WA Fahy… - American journal of …, 2020 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by
scarring of the lung that is believed to result from an atypical response to injury of the …
scarring of the lung that is believed to result from an atypical response to injury of the …
[HTML][HTML] An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study
…, JK Simpson, J Porte, A Habgood, WA Fahy… - The Lancet …, 2017 - thelancet.com
Background Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable
disease trajectory. The aim of this study was to assess potential biomarkers to predict …
disease trajectory. The aim of this study was to assess potential biomarkers to predict …
A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis
…, RC Chambers, AM Groves, WA Fahy… - European …, 2019 - Eur Respiratory Soc
Phosphatidylinositol 3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) play a
role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Omipalisib (GSK2126458) is a …
role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Omipalisib (GSK2126458) is a …
[HTML][HTML] Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort
…, MA Karsdal, CB Nanthakumar, WA Fahy… - Respiratory …, 2019 - Springer
Idiopathic pulmonary fibrosis (IPF) is characterised by excessive extracellular matrix (ECM)
deposition and remodelling. Measuring this activity provides an opportunity to develop tools …
deposition and remodelling. Measuring this activity provides an opportunity to develop tools …
[HTML][HTML] Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study
Background Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease characterised by
progressive scarring leading to alveolar stiffness, reduced lung capacity, and impeded gas …
progressive scarring leading to alveolar stiffness, reduced lung capacity, and impeded gas …
[HTML][HTML] AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD
P Kuna, M Jenkins, CD O'Brien, WA Fahy - Respiratory medicine, 2012 - Elsevier
BACKGROUND: Neutrophil elastase (NE) is implicated in chronic obstructive pulmonary
disease (COPD). AZD9668 is a reversible and selective inhibitor of NE, well tolerated at doses …
disease (COPD). AZD9668 is a reversible and selective inhibitor of NE, well tolerated at doses …
Atmospheric aging enhances the ice nucleation ability of biomass-burning aerosol
Ice-nucleating particles (INPs) in biomass-burning aerosol (BBA) that affect cloud glaciation,
microphysics, precipitation, and radiative forcing were recently found to be driven by the …
microphysics, precipitation, and radiative forcing were recently found to be driven by the …
[HTML][HTML] A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose …
…, A Saleem, AR Kang'ombe, D Fairman, WA Fahy… - Respiratory …, 2020 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with
poor prognosis and a significant unmet medical need. This study evaluated the safety, …
poor prognosis and a significant unmet medical need. This study evaluated the safety, …
[HTML][HTML] Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)
…, J Ramada-Magalhaes, S Moz, WA Fahy… - European Journal of …, 2020 - Springer
Purpose The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis
through activation of transforming growth factor beta (TGFβ). This study sought to quantify …
through activation of transforming growth factor beta (TGFβ). This study sought to quantify …