User profiles for William Apruzzese

William Apruzzese

Brigham and Women's Hospital
Verified email at columbia.edu
Cited by 4213

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

…, N Meednu, C Rozo, W Apruzzese… - Nature …, 2019 - nature.com
To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (…

The immune cell landscape in kidneys of patients with lupus nephritis

…, S Steelman, DE Smilek, P Tosta, W Apruzzese… - Nature …, 2019 - nature.com
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is
ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed …

Musculoskeletal disorders of the hand and shoulder in patients with diabetes mellitus

E Cagliero, W Apruzzese, GS Perlmutter… - The American journal of …, 2002 - amjmed.com
Results About 60% of the patients and controls were men (Table 1). Both retinopathy and
neuropathy were common in diabetic patients. The prevalence of musculoskeletal disorders …

[HTML][HTML] Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes

…, M Curtis, Q Xiao, M Gutierrez-Arcelus, W Apruzzese… - Nature, 2023 - nature.com
Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction 1 . There is currently no cure for rheumatoid arthritis, and the effectiveness of …

Low‐level laser therapy for zymosan‐induced arthritis in rats: Importance of illumination time

…, I Yaroslavsky, R Cohen, WA Apruzzese… - Lasers in Surgery …, 2007 - Wiley Online Library
Background It has been proposed for many years that low‐level laser (or light) therapy (LLLT)
can ameliorate the pain, swelling, and inflammation associated with various forms of …

Urine proteomics and renal single‐cell transcriptomics implicate interleukin‐16 in lupus nephritis

…, D Wofsy, S Raychaudhuri, W Apruzzese… - Arthritis & …, 2022 - Wiley Online Library
Objective Current lupus nephritis (LN) treatments are effective in only 30% of patients,
emphasizing the need for novel therapeutic strategies. We undertook this study to develop …

[HTML][HTML] Bile acid binding to sevelamer HCl

W Braunlin, E Zhorov, A Guo, W Apruzzese, Q Xu… - Kidney international, 2002 - Elsevier
… Author links open overlay panel William Braunlin , Eugene Zhorov , Amy Guo , William
Apruzzese , Qiuwei Xu , Patrick Hook , David L. Smisek , W. Harry Mandeville , S. …

Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritis

…, N Millard, Q Xiao, M Gutierrez-Arcelus, W Apruzzese… - BioRxiv, 2022 - biorxiv.org
Rheumatoid arthritis (RA) is a prototypical autoimmune disease that causes destructive
tissue inflammation in joints and elsewhere. Clinical challenges in RA include the empirical …

[HTML][HTML] Integrated urine proteomics and renal single-cell genomics identify an IFN-γ response gradient in lupus nephritis

…, B Diamond, N Hacohen, D Wofsy, W Apruzzese… - JCI insight, 2020 - ncbi.nlm.nih.gov
Lupus nephritis, one of the most serious manifestations of systemic lupus erythematosus (SLE),
has a heterogeneous clinical and pathological presentation. For example, proliferative …

Axillary nerve injuries in contact sports: recommendations for treatment and rehabilitation

GS Perlmutter, W Apruzzese - Sports Medicine, 1998 - Springer
Axillary nerve injuries are some of the most common peripheral nerve injuries in athletes
who participate in contact sports. Resulting deltoid muscle paralysis is secondary to nerve …