Dietary restriction (DR) without malnutrition encompasses numerous regimens with overlapping
benefits including longevity and stress resistance, but unifying nutritional and molecular …

When energy supply is low, organisms respond by slowing aging and increasing resistance
to diverse age-related pathologies. Targeting the mechanisms underpinning this response …

Mitochondria undergo architectural/functional changes in response to metabolic inputs. How
this process is regulated in physiological feeding/fasting states remains unclear. Here we …

Mitochondrial network remodeling between fused and fragmented states facilitates mitophagy,
interaction with other organelles, and metabolic flexibility. Aging is associated with a loss …

Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But
the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an …

Chromatin and metabolic states both influence lifespan, but how they interact in lifespan
regulation is largely unknown. The COMPASS chromatin complex, which trimethylates lysine 4 …

Mild inhibition of mitochondrial respiration extends the lifespan of many species. In
Caenorhabditis elegans, reactive oxygen species (ROS) promote longevity by activating hypoxia-…

Ageing is driven by a loss of transcriptional and protein homeostasis 1 , 2 , 3 and is the key
risk factor for multiple chronic diseases. Interventions that attenuate or reverse systemic …

Low energy states delay aging in multiple species, yet mechanisms coordinating energetics
and longevity across tissues remain poorly defined. The conserved energy sensor AMP-…

Alternative pre-mRNA splicing increases the complexity of the proteome that can be generated
from the available genomic coding sequences. Dysregulation of the splicing process has …