Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of
NO synthase (NOS; EC 1.14.13.39). They all utilize l-arginine and molecular oxygen as …

Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for
maintaining systemic blood pressure, vascular remodelling and angiogenesis 1 , 2 , 3 , 4 . …

Inflammation is usually analysed from the perspective of tissue-infiltrating leukocytes.
Microvascular endothelial cells at a site of inflammation are both active participants in and …

Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) is expressed
primarily in the hypothalamus. Here, it is shown that OB-Rb is also expressed in human …

Recent studies suggest that statins can function to protect the vasculature in a manner that
is independent of their lipid-lowering activity. We show here that statins rapidly activate the …

Vascular endothelial growth factor (VEGF) is a regulator of vasculogenesis and angiogenesis.
To investigate the role of nitric oxide (NO) in VEGF-induced proliferation and in vitro …

Recently, we have shown that chronic exercise increases endothelium-derived relaxing factor
(EDRF)/nitric oxide (NO)-mediated epicardial coronary artery dilation in response to brief …

Caveolae were originally identified as ffask-shaped invaginations of the plasma membrane
in endothelial and epithelial cells (14). Prior to the development of biochemical methods for …

Heat-shock protein 90 (Hsp90) coordinates the trafficking and regulation of diverse signalling
proteins, but its precise role in regulating specific cellular targets is not known 1 , 2 . Here …

Nitric oxide produced in endothelial cells affects vascular tone. To investigate the role of
endothelial nitric oxide synthase (eNOS) in blood pressure regulation, we have generated mice …