The immune system influences the fate of developing cancers by not only functioning as a
tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts …

EpCAM (epithelial cell adhesion molecule) is a cell surface molecule that is known to be
highly expressed in colon and other epithelial carcinomas. EpCAM is involved in cell-to-cell …

Conventional type 1 dendritic cells (cDC1) 1 are thought to perform antigen cross-presentation,
which is required to prime CD8 + T cells 2 , 3 , whereas cDC2 are specialized for priming …

Tumors evade immune destruction by actively inducing immune tolerance through the
recruitment of CD4+ CD25+ Foxp3+ regulatory T cells (Treg). We have previously described …

Background The benefit of surgical resection in patients presenting with metastatic breast
cancer is not established. We hypothesized that surgical excision of primary tumors in patients …

Objective Chemokine pathways are co-opted by pancreatic adenocarcinoma (PDAC) to
facilitate myeloid cell recruitment from the bone marrow to establish an immunosuppressive …

Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and
therapeutic resistance—involve complex interactions between cells within the dynamic tumor …

Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …

Purpose Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of
immunosuppressive cells that are upregulated in cancer. Little is known about the prevalence …

During the process of cross-presentation, viral or tumor-derived antigens are presented to
CD8 + T cells by Batf3-dependent CD8α + /XCR1 + classical dendritic cells (cDC1s). We …