RNAse A mismatch cleavage analysis of 66 primary human colon tumours reveals a high
incidence of K-ras genes with mutations at position 12. No apparent correlation was found …

Specimen collection is an integral component of clinical research. Specimens from subjects
with various stages of cancers or other conditions, as well as those without disease, are …

Rationale: The impact of modern treatments of pulmonary arterial hypertension (PAH) on
pulmonary vascular pathology remains unknown. Objectives: To assess the spectrum of …

Myeloid‐derived suppressor cells (MDSCs) promote tumor progression. The mechanisms of
MDSC development during tumor growth remain unknown. Tumor exosomes (T‐exosomes) …

Many tumor cells shed specialized membrane vesicles known as exosomes. In this study, we
show that pretreatment of mice with exosomes produced by TS/A or 4T. 1 murine mammary …

Evidence suggests that the histone deacetylase, SIRT1, is a mediator of life span extension
by calorie restriction; however, SIRT1 may paradoxically increase the risk of cancer. To …

OBJECTIVE We sought to determine whether exosome-like vesicles (ELVs) released from
adipose tissue play a role in activation of macrophages and subsequent development of …

The production of exosomes by tumor cells has been implicated in tumor-associated immune
suppression. In this study, we show that, in mice, exosomes produced by TS/A murine …

Tumor growth promotes the expansion of myeloid suppressor cells. An inverse correlation
between natural killer (NK) cell activation and myeloid suppressor cell (MSC) expansion in …

Normal and diseased cells release bilayered membrane-bound nanovesicles into interstitial
spaces and into bodily fluids. A subgroup of such microvesicles is called exosomes and is …