User profiles for William J Nicolas

William Jules Nicolas

Howard Hughes Medical Institute - Gonen lab UCLA
Verified email at g.ucla.edu
Cited by 900

Architecture and permeability of post-cytokinesis plasmodesmata lacking cytoplasmic sleeves

WJ Nicolas, MS Grison, S Trépout, A Gaston, M Fouché… - Nature plants, 2017 - nature.com
Plasmodesmata are remarkable cellular machines responsible for the controlled exchange
of proteins, small RNAs and signalling molecules between cells. They are lined by the …

Multiple C2 domains and transmembrane region proteins (MCTP s) tether membranes at plasmodesmata

ML Brault, JD Petit, F Immel, WJ Nicolas, M Glavier… - EMBO …, 2019 - embopress.org
In eukaryotes, membrane contact sites ( MCS ) allow direct communication between
organelles. Plants have evolved a unique type of MCS , inside intercellular pores, the …

Bdellovibrio predation cycle characterized at nanometre-scale resolution with cryo-electron tomography

M Kaplan, YW Chang, CM Oikonomou, WJ Nicolas… - Nature …, 2023 - nature.com
Bdellovibrio bacteriovorus is a microbial predator that offers promise as a living antibiotic for
its ability to kill Gram-negative bacteria, including human pathogens. Even after six decades …

[PDF][PDF] Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks

WJ Nicolas, F Fäßler, P Dutka, FKM Schur, G Jensen… - Current Biology, 2022 - cell.com
One hallmark of plant cells is their cell wall. They protect cells against the environment and
high turgor and mediate morphogenesis through the dynamics of their mechanical and …

Sphingolipid biosynthesis modulates plasmodesmal ultrastructure and phloem unloading

D Yan, SR Yadav, A Paterlini, WJ Nicolas, JD Petit… - Nature plants, 2019 - nature.com
During phloem unloading, multiple cell-to-cell transport events move organic substances to
the root meristem. Although the primary unloading event from the sieve elements to the …

[HTML][HTML] A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals

…, WJ Nicolas, SJ Weaver, J Hattne… - Nature …, 2023 - nature.com
Crystallizing G protein-coupled receptors (GPCRs) in lipidic cubic phase (LCP) often yields
crystals suited for the cryogenic electron microscopy (cryoEM) method microcrystal electron …

Structure of the bacterial cellulose ribbon and its assembly-guiding cytoskeleton by electron cryotomography

WJ Nicolas, D Ghosal, EI Tocheva… - Journal of …, 2021 - Am Soc Microbiol
Cellulose is a widespread component of bacterial biofilms, where its properties of exceptional
water retention, high tensile strength, and stiffness prevent dehydration and mechanical …

In situ imaging of bacterial outer membrane projections and associated protein complexes using electron cryo-tomography

…, J Liedtke, CR Wood, CM Oikonomou, WJ Nicolas… - Elife, 2021 - elifesciences.org
The ability to produce outer membrane projections in the form of tubular membrane
extensions (MEs) and membrane vesicles (MVs) is a widespread phenomenon among diderm …

Dare to change, the dynamics behind plasmodesmata-mediated cell-to-cell communication

JD Petit, ZP Li, WJ Nicolas, MS Grison… - Current Opinion in Plant …, 2020 - Elsevier
Plasmodesmata pores control the entry and exit of molecules at cell-to-cell boundaries.
Hundreds of pores perforate the plant cell wall, connecting cells together and establishing direct …

Shaping intercellular channels of plasmodesmata: the structure-to-function missing link

WJ Nicolas, MS Grison, EM Bayer - Journal of experimental …, 2018 - academic.oup.com
Plasmodesmata (PD) are a hallmark of the plant kingdom and a cornerstone of plant biology
and physiology, forming the conduits for the cell-to-cell transfer of proteins, RNA and …