User profiles for William J. O’Shaughnessy
William J O'ShaughnessyUT Southwestern Medical Center Verified email at UTsouthwestern.edu Cited by 171 |
Toxoplasma ERK7 protects the apical complex from premature degradation
WJ O'Shaughnessy, X Hu, SA Henriquez… - Journal of Cell …, 2023 - rupress.org
Accurate cellular replication balances the biogenesis and turnover of complex structures. In
the apicomplexan parasite Toxoplasma gondii, daughter cells form within an intact mother …
the apicomplexan parasite Toxoplasma gondii, daughter cells form within an intact mother …
Divergent kinase regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole
…, JC Young, WJ O'Shaughnessy… - Proceedings of the …, 2019 - National Acad Sciences
Apicomplexan parasites replicate within a protective organelle, called the parasitophorous
vacuole (PV). The Toxoplasma gondii PV is filled with a network of tubulated membranes, …
vacuole (PV). The Toxoplasma gondii PV is filled with a network of tubulated membranes, …
Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis
PS Back, WJ O'Shaughnessy… - Proceedings of the …, 2020 - National Acad Sciences
Apicomplexan parasites use a specialized cilium structure called the apical complex to
organize their secretory organelles and invasion machinery. The apical complex is integrally …
organize their secretory organelles and invasion machinery. The apical complex is integrally …
Loss of a conserved MAPK causes catastrophic failure in assembly of a specialized cilium-like structure in Toxoplasma gondii
WJ O'Shaughnessy, X Hu, T Beraki… - Molecular biology of …, 2020 - Am Soc Cell Biol
Primary cilia are important organizing centers that control diverse cellular processes.
Apicomplexan parasites like Toxoplasma gondii have a specialized cilium-like structure called the …
Apicomplexan parasites like Toxoplasma gondii have a specialized cilium-like structure called the …
[HTML][HTML] Cryo-tomography reveals rigid-body motion and organization of apicomplexan invasion machinery
The apical complex is a specialized collection of cytoskeletal and secretory machinery in
apicomplexan parasites, which include the pathogens that cause malaria and toxoplasmosis. …
apicomplexan parasites, which include the pathogens that cause malaria and toxoplasmosis. …
Multivalent Interactions Drive the Toxoplasma AC9:AC10:ERK7 Complex To Concentrate ERK7 in the Apical Cap
PS Back, WJ O'Shaughnessy, AS Moon, PS Dewangan… - MBio, 2022 - Am Soc Microbiol
The Toxoplasma inner membrane complex (IMC) is a specialized organelle that is crucial for
the parasite to establish an intracellular lifestyle and ultimately cause disease. The IMC is …
the parasite to establish an intracellular lifestyle and ultimately cause disease. The IMC is …
[HTML][HTML] Not your Mother's MAPKs: Apicomplexan MAPK function in daughter cell budding
WJ O'Shaughnessy, PS Dewangan, EA Paiz… - PLoS …, 2022 - journals.plos.org
Reversible phosphorylation by protein kinases is one of the core mechanisms by which
biological signals are propagated and processed. Mitogen-activated protein kinases, or MAPKs, …
biological signals are propagated and processed. Mitogen-activated protein kinases, or MAPKs, …
Loss of the Conserved Alveolate Kinase MAPK2 Decouples Toxoplasma Cell Growth from Cell Division
Mitogen-activated protein kinases (MAPKs) are a conserved family of protein kinases that
regulate signal transduction, proliferation, and development throughout eukaryotes. The …
regulate signal transduction, proliferation, and development throughout eukaryotes. The …
Toxoplasma ERK7 defends the apical complex from premature degradation
WJ O'Shaughnessy, X Hu, SA Henriquez, ML Reese - bioRxiv, 2021 - biorxiv.org
Accurate cellular replication balances the biogenesis and turnover of complex structures.
Apicomplexan parasites such as Plasmodium and Toxoplasma replicate by forming daughter …
Apicomplexan parasites such as Plasmodium and Toxoplasma replicate by forming daughter …
Cryo-electron tomography of the apicomplexan invasion machinery in its native state reveals rigid body motion of the conoid and docked secretory machinery
The apical complex is a conserved cytoskeletal structure that organizes the secretory and
invasion machinery of all apicomplexan parasites, the causative agents of diseases such as …
invasion machinery of all apicomplexan parasites, the causative agents of diseases such as …