User profiles for William J. O’Shaughnessy

William J O'Shaughnessy

UT Southwestern Medical Center
Verified email at UTsouthwestern.edu
Cited by 171

Toxoplasma ERK7 protects the apical complex from premature degradation

WJ O'Shaughnessy, X Hu, SA Henriquez… - Journal of Cell …, 2023 - rupress.org
Accurate cellular replication balances the biogenesis and turnover of complex structures. In
the apicomplexan parasite Toxoplasma gondii, daughter cells form within an intact mother …

Divergent kinase regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole

…, JC Young, WJ O'Shaughnessy… - Proceedings of the …, 2019 - National Acad Sciences
Apicomplexan parasites replicate within a protective organelle, called the parasitophorous
vacuole (PV). The Toxoplasma gondii PV is filled with a network of tubulated membranes, …

Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis

PS Back, WJ O'Shaughnessy… - Proceedings of the …, 2020 - National Acad Sciences
Apicomplexan parasites use a specialized cilium structure called the apical complex to
organize their secretory organelles and invasion machinery. The apical complex is integrally …

Loss of a conserved MAPK causes catastrophic failure in assembly of a specialized cilium-like structure in Toxoplasma gondii

WJ O'Shaughnessy, X Hu, T Beraki… - Molecular biology of …, 2020 - Am Soc Cell Biol
Primary cilia are important organizing centers that control diverse cellular processes.
Apicomplexan parasites like Toxoplasma gondii have a specialized cilium-like structure called the …

[HTML][HTML] Cryo-tomography reveals rigid-body motion and organization of apicomplexan invasion machinery

L Gui, WJ O'Shaughnessy, K Cai, E Reetz… - Nature …, 2023 - nature.com
The apical complex is a specialized collection of cytoskeletal and secretory machinery in
apicomplexan parasites, which include the pathogens that cause malaria and toxoplasmosis. …

Multivalent Interactions Drive the Toxoplasma AC9:AC10:ERK7 Complex To Concentrate ERK7 in the Apical Cap

PS Back, WJ O'Shaughnessy, AS Moon, PS Dewangan… - MBio, 2022 - Am Soc Microbiol
The Toxoplasma inner membrane complex (IMC) is a specialized organelle that is crucial for
the parasite to establish an intracellular lifestyle and ultimately cause disease. The IMC is …

[HTML][HTML] Not your Mother's MAPKs: Apicomplexan MAPK function in daughter cell budding

WJ O'Shaughnessy, PS Dewangan, EA Paiz… - PLoS …, 2022 - journals.plos.org
Reversible phosphorylation by protein kinases is one of the core mechanisms by which
biological signals are propagated and processed. Mitogen-activated protein kinases, or MAPKs, …

Loss of the Conserved Alveolate Kinase MAPK2 Decouples Toxoplasma Cell Growth from Cell Division

X Hu, WJ O'shaughnessy, TG Beraki, ML Reese - MBio, 2020 - Am Soc Microbiol
Mitogen-activated protein kinases (MAPKs) are a conserved family of protein kinases that
regulate signal transduction, proliferation, and development throughout eukaryotes. The …

Toxoplasma ERK7 defends the apical complex from premature degradation

WJ O'Shaughnessy, X Hu, SA Henriquez, ML Reese - bioRxiv, 2021 - biorxiv.org
Accurate cellular replication balances the biogenesis and turnover of complex structures.
Apicomplexan parasites such as Plasmodium and Toxoplasma replicate by forming daughter …

Cryo-electron tomography of the apicomplexan invasion machinery in its native state reveals rigid body motion of the conoid and docked secretory machinery

L Gui, WJ O'Shaughnessy, K Cai, E Reetz, ML Reese… - bioRxiv, 2022 - biorxiv.org
The apical complex is a conserved cytoskeletal structure that organizes the secretory and
invasion machinery of all apicomplexan parasites, the causative agents of diseases such as …