The cellular and molecular mechanisms that underlie species-specific membrane fusion
between male and female gametes remain largely unknown. Here, by use of gene discovery …

Biologists have long known that humans experience their environment through cilia. Light,
odorant, and sound perception depend on these microtubule-filled, complex organelles …

Cilia and flagella are important organizing centers for signaling in both development and
disease. A key to their function is a poorly characterized barrier at their base that allows the …

). This review focuses on mammalian fertilization (primarily in the mouse) and in particular
on proteins involved in the cell–cell adhesion, fusion, and signaling events that ensue when …

Sexual reproduction is almost universal in eukaryotic life and involves the fusion of male
and female haploid gametes into a diploid cell. The sperm-restricted single-pass …

Cilia and flagella play key roles in development and sensory transduction, and several human
disorders, including polycystic kidney disease, are associated with the failure to assemble …

Izumo, a sperm membrane protein, is essential for gamete fusion in the mouse. It has an
Immunoglobulin (Ig) domain and an N‐terminal domain for which neither the functions nor …

Primary cilia are widely used for signal transduction during development and in homeostasis
and are assembled and maintained by intraflagellar transport (IFT). Here, we have …

Cilia and flagella are dynamic organelles that are assembled and disassembled during cell
differentiation, during stress, and during the cell cycle. Although intraflagellar transport (IFT) …

10.7554/eLife.05242.001 The role of the primary cilium in key signaling pathways depends
on dynamic regulation of ciliary membrane protein composition, yet we know little about the …