Structure of the 30S ribosomal subunit
Genetic information encoded in messenger RNA is translated into protein by the ribosome,
which is a large nucleoprotein complex comprising two subunits, denoted 30S and 50S in …
which is a large nucleoprotein complex comprising two subunits, denoted 30S and 50S in …
Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
The 30S ribosomal subunit has two primary functions in protein synthesis. It discriminates
against aminoacyl transfer RNAs that do not match the codon of messenger RNA, thereby …
against aminoacyl transfer RNAs that do not match the codon of messenger RNA, thereby …
Recognition of Cognate Transfer RNA by the 30S Ribosomal Subunit
JM Ogle, DE Brodersen, WM Clemons Jr, MJ Tarry… - Science, 2001 - science.org
Crystal structures of the 30S ribosomal subunit in complex with messenger RNA and cognate
transfer RNA in the A site, both in the presence and absence of the antibiotic paromomycin…
transfer RNA in the A site, both in the presence and absence of the antibiotic paromomycin…
X-ray structure of a protein-conducting channel
A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms
a protein-conducting channel, allowing polypeptides to be transferred across or integrated …
a protein-conducting channel, allowing polypeptides to be transferred across or integrated …
[HTML][HTML] The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit
We have used the recently determined atomic structure of the 30S ribosomal subunit to
determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and …
determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and …
Crystal Structure of an Initiation Factor Bound to the 30S Ribosomal Subunit
Initiation of translation at the correct position on messenger RNA is essential for accurate
protein synthesis. In prokaryotes, this process requires three initiation factors: IF1, IF2, and IF3. …
protein synthesis. In prokaryotes, this process requires three initiation factors: IF1, IF2, and IF3. …
Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA
We present a detailed analysis of the protein structures in the 30 S ribosomal subunit from
Thermus thermophilus, and their interactions with 16 S RNA based on a crystal structure at …
Thermus thermophilus, and their interactions with 16 S RNA based on a crystal structure at …
Structure of a bacterial 30S ribosomal subunit at 5.5 Å resolution
WM Clemons Jr, JLC May, BT Wimberly… - Nature, 1999 - nature.com
The 30S ribosomal subunit binds messenger RNA and the anticodon stem-loop of transfer
RNA during protein synthesis. A crystallographic analysis of the structure of the subunit from …
RNA during protein synthesis. A crystallographic analysis of the structure of the subunit from …
Crystal structure of the long-chain fatty acid transporter FadL
The mechanisms by which hydrophobic molecules, such as long-chain fatty acids, enter cells
are poorly understood. In Gram-negative bacteria, the lipopolysaccharide layer in the outer …
are poorly understood. In Gram-negative bacteria, the lipopolysaccharide layer in the outer …
Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY
KS Cannon, E Or, WM Clemons Jr, Y Shibata… - The Journal of cell …, 2005 - rupress.org
During their biosynthesis, many proteins pass through the membrane via a hydrophilic
channel formed by the heterotrimeric Sec61/SecY complex. Whether this channel forms at the …
channel formed by the heterotrimeric Sec61/SecY complex. Whether this channel forms at the …