Mitophagy is a form of selective autophagy that disposes of superfluous and potentially
damage-inducing organelles in a tightly controlled manner. While the machinery involved in …

Voltage-dependent anion channel (VDAC), the most abundant mitochondrial outer membrane
protein, is important for a variety of mitochondrial functions including metabolite exchange…

Voltage-dependent anion channel (VDAC) is the most ubiquitous channel at the mitochondrial
outer membrane, and is believed to be the pathway for calcium entering or leaving the …

There is accumulating evidence that endogenous steroids and non-polar drugs are involved
in the regulation of mitochondrial physiology. Many of these hydrophobic compounds …

To gain insight into the conformational properties and compaction of megabase-long chromatin
molecules, we reconstituted chromatin from T4 phage DNA (165 kb) and recombinant …

Involvement of alpha-synuclein (αSyn) in Parkinson’s disease (PD) is complicated and difficult
to trace on cellular and molecular levels. Recently, we established that αSyn can regulate …

Using the gramicidin A channel as a molecular probe, we show that tubulin binding to planar
lipid membranes changes the channel kinetics—seen as an increase in the lifetime of the …

Human p97 is a potential drug target in oncology. Mutation‐driven drug resistance is an
obstacle to the long‐term efficacy of targeted therapy. We found that the ATPase activity for one …

The diverse modes of action of small molecule inhibitors provide versatile tools to investigate
basic biology and develop therapeutics. However, it remains a challenging task to evaluate …

… Author links open overlay panel William M. Rosencrans a b 1 , Zachary H. Walsh a c 1 , Nadia
Houerbi a , Andrew Blum a , Mezmur Belew a d , Changchang Liu a e , Brian Chernak a f , …