Rapid sensory adaptation is observed across all sensory systems, and strongly shapes
sensory percepts in complex sensory environments. Yet despite its ubiquity and likely necessity …

Background Whole-cell patch-clamp recording in vivo is the gold-standard method for
measuring subthreshold electrophysiology from single cells during behavioural tasks, sensory …

Significant technical challenges exist when measuring synaptic connections between
neurons in living brain tissue. The patch clamping technique, when used to probe for synaptic …

Patch clamp is the main technique for measuring electrical properties of individual cells.
Since its discovery in 1976 by Neher and Sakmann, patch clamp has been instrumental in …

Major Depressive Disorder (MDD) is associated with impaired processing and regulation of
emotions. A vast body of research has elucidated the altered neural processes that occur in …

• It is well established that individual organisms can acclimate and adapt to temperature to
optimize their functioning. However, thermal optimization of ecosystems, as an assemblage of …

Biosensors exploiting communication within genetically engineered bacteria are becoming
increasingly important for monitoring environmental changes. Currently, there are a variety of …

Patch clamping is the gold standard measurement technique for cell-type characterization in
vivo, but it has low throughput, is difficult to scale, and requires highly skilled operation. We …

Objective. Intracellular patch-clamp electrophysiology, one of the most ubiquitous, high-fidelity
techniques in biophysics, remains laborious and low-throughput. While previous efforts …

In vivo studies of neurophysiology using the whole cell patch-clamp technique enable
exquisite access to both intracellular dynamics and cytosol of cells in the living brain but are …