Current human pluripotent stem cells lack the transcription factor circuitry that governs the
ground state of mouse embryonic stem cells (ESC). Here, we report that short-term expression …

Mouse embryonic stem (ES) cells derived from pluripotent early epiblast contribute functionally
differentiated progeny to all foetal lineages of chimaeras. By contrast, epistem cell (EpiSC…

Naive pluripotent embryonic stem cells (ESCs) and embryonic germ cells (EGCs) are
derived from the preimplantation epiblast and primordial germ cells (PGCs), respectively. We …

Embryonic stem cell (ESC) pluripotency is dependent on an intrinsic gene regulatory
network centered on Oct4. Propagation of the pluripotent state is stimulated by the cytokine …

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …

Climate-driven redistribution of tuna threatens to disrupt the economies of Pacific Small Island
Developing States (SIDS) and sustainable management of the world’s largest tuna fishery. …

Transcriptional heterogeneity within embryonic stem cell (ESC) populations has been
suggested as a mechanism by which a seemingly homogeneous cell population can initiate …

… The availability of these cells will not only enable the dissection … Genetic manipulation via
NOD ES cells will enable geneticists … These results indicate that our NOD ES cells will indeed …

The transcription factor Oct4 is required in vitro for establishment and maintenance of embryonic
stem cells and for reprogramming somatic cells to pluripotency. In vivo, it prevents the …

Mouse and rat embryonic stem cells can be sustained in defined medium by dual inhibition (2i)
of the mitogen-activated protein kinase (Erk1/2) cascade and of glycogen synthase …