Rationale: Independent replication of genetic associations in complex diseases, particularly
in whole-genome association studies, is critical to confirm the association. Objectives: A …

Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide
variation from this region remain largely uncharacterized. We studied genomic …

Background Asthma is a complex disease with both genetic and environmental causes.
Genome-wide association studies of asthma have mostly involved European populations, and …

Most individuals throughout the Americas are admixed descendants of Native American,
European, and African ancestors. Complex historical factors have resulted in varying …

Background The coexistence of obstructive sleep apnea (OSA) and chronic obstructive
pulmonary diseases (COPD) is known as overlap syndrome (OS); it occurs in 10–20% of patients …

Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

… Rodriguez-Cintron recruited and characterized subjects whose data were analyzed as part
… William Rodriguez-Cintron is with the Veterans Affairs Medical Center, University of Puerto …

Background Self-identified race or ethnic group is used to determine normal reference standards
in the prediction of pulmonary function. We conducted a study to determine whether the …

… We will first develop the theoretical underpinnings of our method and explain its connections
to … SNPs will be chosen to correlate with the top principal components, and thus we will call …

Background The primary rescue medication to treat acute asthma exacerbation is the short-acting
β 2 -adrenergic receptor agonist; however, there is variation in how well a patient …