Multifactor dimensionality reduction (MDR) was developed as a method for detecting statistical
patterns of epistasis. The overall goal of MDR is to change the representation space of …

Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful
tool for investigating the genetic architecture of human disease. In this work, we review …

Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …

Many modern human genomes retain DNA inherited from interbreeding with archaic
hominins, such as Neandertals, yet the influence of this admixture on human traits is largely …

Background— Although the inverse association between high-density lipoprotein cholesterol
(HDL-C) and risk of cardiovascular disease (CVD) has been long established, it remains …

Importance Large-scale DNA sequencing identifies incidental rare variants in established
Mendelian disease genes, but the frequency of related clinical phenotypes in unselected …

Advances in genotyping technology have, over the past decade, enabled the focused search
for common genetic variation associated with human diseases and traits. With the recently …

Genetic variation can affect drug response in multiple ways, although it remains unclear how
rare genetic variants affect drug response. The electronic Medical Records and Genomics (…

The Alzheimer’s Disease Sequencing Project (ADSP) undertook whole exome sequencing
in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal controls …