The serine/threonine kinase Akt has been implicated in the control of cell survival and
metabolism. Here we report the disruption of the most ubiquitously expressed member of theakt …

To elucidate the functions of the serine/threonine kinase Akt/PKB in vivo, we generated mice
lacking both akt1 and akt2 genes. Akt1/Akt2 double-knockout (DKO) mice exhibit severe …

The high-dimensional data created by high-throughput technologies require visualization
tools that reveal data structure and patterns in an intuitive form. We present PHATE, a …

HNF-36, a transcription factor of the winged-helix family, is expressed in embryonic and
adult endoderm and also in midline cells of the node, notochord, and floor plate in mouse …

Expression of HNF-4, a transcription factor in the steroid hormone receptor superfamily, is
detected only in the visceral endoderm of mouse embryos during gastrulation and is …

Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …

The expression of HNF-4 (hepatocyte nuclear factor 4) mRNA in postimplantation mouse
embryos was analyzed by in situ hybridization. Expression was found in the primary endoderm …

The epidermal growth factor (EGF) receptor is a transmembrane glycoprotein of relative
molecular mass 170,000 with intrinsic ligand-dependent protein tyrosine kinase activity 1–6 . …

Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
pleiotropic and systemic effects in some individuals 1 , 2 – 3 , many others experience …

Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole-genome …