Massively parallel DNA sequencing technologies provide an unprecedented ability to
screen entire genomes for genetic changes associated with tumour progression. Here we …

Genome wide association studies are central to the evolution of personalized medicine.
However, the propensity for single nucleotide polymorphisms (SNPs) to fall outside of genes …

To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with
somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two …

Massively parallel sequencing technology and the associated rapidly decreasing sequencing
costs have enabled systemic analyses of somatic mutations in large cohorts of cancer …

The sensitivity of massively-parallel sequencing has confirmed that most cancers are
oligoclonal, with subpopulations of neoplastic cells harboring distinct mutations. A fine resolution …

In the past decade, precision genomics based medicine has emerged to provide tailored
and effective healthcare for patients depending upon their genetic features. Genome Wide …

Early childhood growth patterns are associated with adult health, yet the genetic factors and
the developmental stages involved are not fully understood. Here, we combine genome-…

In this work, we present the Genome Modeling System (GMS), an analysis information
management system capable of executing automated genome analysis pipelines at a massive …

Background The purpose of this study was to further elucidate the role of the vascular smooth
muscle cells (SMCs) in abdominal aortic aneurysm (AAA) disease. We hypothesized that …

Importance Treatment of pediatric obesity is challenging. Preclinical studies in mice indicated
that weight and metabolism can be altered by gut microbiome manipulation. Objective To …