User profiles for William Wiley Navarre

William Navarre

Professor of Molecular Genetics, University of Toronto
Verified email at utoronto.ca
Cited by 8932

Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope

WW Navarre, O Schneewind - Microbiology and molecular biology …, 1999 - Am Soc Microbiol
The cell wall envelope of gram-positive bacteria is a macromolecular, exoskeletal organelle
that is assembled and turned over at designated sites. The cell wall also functions as a …

Selective Silencing of Foreign DNA with Low GC Content by the H-NS Protein in Salmonella

WW Navarre, S Porwollik, Y Wang, M McClelland… - Science, 2006 - science.org
Horizontal gene transfer plays a major role in microbial evolution. However, newly acquired
sequences can decrease fitness unless integrated into preexisting regulatory networks. We …

Proteolytic cleavage and cell wall anchoring at the LPXTG motif of surface proteins in Gram‐positive bacteria

WW Navarre, O Schneewind - Molecular microbiology, 1994 - Wiley Online Library
Many surface proteins are thought to be anchored to the cell wall of Gram‐positive bacteria
via their C‐terminus. Cell wall anchoring requires a specific sorting signal, normally located …

Silencing of xenogeneic DNA by H-NS—facilitation of lateral gene transfer in bacteria by a defense system that recognizes foreign DNA

WW Navarre, M McClelland, SJ Libby… - Genes & …, 2007 - genesdev.cshlp.org
Lateral gene transfer has played a prominent role in bacterial evolution, but the mechanisms
allowing bacteria to tolerate the acquisition of foreign DNA have been incompletely defined. …

Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides

MW Bader, WW Navarre, W Shiau… - Molecular …, 2003 - Wiley Online Library
Cationic antimicrobial peptides (CAMP) represent a conserved and highly effective
component of innate immunity. During infection, the Gram‐negative pathogen Salmonella …

Co‐regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ

WW Navarre, TA Halsey, D Walthers… - Molecular …, 2005 - Wiley Online Library
Analysis of the transcriptome of slyA mutant Salmonella enterica serovar Typhimurium revealed
that many SlyA‐dependent genes, including pagC, pagD, ugtL, mig‐14, virK, phoN, pgtE…

[HTML][HTML] Multiple enzymatic activities of the murein hydrolase from staphylococcal phage φ11: Identification of a D-alanyl-glycine endopeptidase activity

WW Navarre, H Ton-That, KF Faull… - Journal of Biological …, 1999 - ASBMB
Bacteriophage muralytic enzymes degrade the cell wall envelope of staphylococci to release
phage particles from the bacterial cytoplasm. Murein hydrolases of staphylococcal phages …

Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis

…, H Van Bakel, S Tian, WW Navarre… - Proceedings of the …, 2010 - National Acad Sciences
Bacterial nucleoid-associated proteins play important roles in chromosome organization
and global gene regulation. We find that Lsr2 of Mycobacterium tuberculosis is a unique …

Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins

…, P Ding, TR Hughes, WW Navarre… - Proceedings of the …, 2011 - National Acad Sciences
H-NS and Lsr2 are nucleoid-associated proteins from Gram-negative bacteria and Mycobacteria,
respectively, that play an important role in the silencing of horizontally acquired foreign …

Pathogen‐induced apoptosis of macrophages: a common end for different pathogenic strategies: Microreview

WW Navarre, A Zychlinsky - Cellular microbiology, 2000 - Wiley Online Library
Microbe–macrophage interactions play a central role in the pathogenesis of many infections.
Several bacterial pathogens induce apoptosis specifically in macrophages, but the …