Background Hereditary angioedema is characterized by recurrent attacks of angioedema of
the skin, larynx, and gastrointestinal tract. Bradykinin is the key mediator of symptoms. …

BACKGROUND: Specific immunotherapy is the only treatment modality that has the potential
to alter the natural course of allergic diseases. Sublingual immunotherapy has been …

ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive
patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC…

Background Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal
antibody that has been shown to safely reduce exacerbations and improve lung function for …

In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …

Upon engagement of the B Cell Receptor (BCR) of WEHI 231 immature B cells, a drop in c-Myc
expression is followed by activation of the cyclin-dependent kinase inhibitor (CKI) p27 …

Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress, …

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Background Hereditary angioedema is a disabling, potentially fatal condition caused by
deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein. In a phase 2 trial, the use of …

… We hope that the algorithm will be validated by treatment teams … We hope that this approach
will be openly discussed and modified … that will encourage undertaking further clinical trials. …