One of the primary tools that researchers use to predict risk is the case-control study. We
identify a flaw, temporal bias, that is specific to and uniquely associated with these studies that …

Abstract Machine learning can help clinicians to make individualized patient predictions only
if researchers demonstrate models that contribute novel insights, rather than learning the …

We describe a new library generation method, Machine-based Identification of Molecules
Inside Characterized Space (MIMICS), that generates sets of molecules inspired by a text-…

Histopathologic evaluation of biopsy slides is a critical step in diagnosing and subtyping breast
cancers. However, the connections between histology and multi-omics status have never …

A randomized, 4-week, double-blind trial followed by an open-label extension trial assessed
the efficacy and safety of a once-daily, extended-release morphine formulation (Avinza™ (…

Background While acute kidney injury (AKI) is a common complication in COVID-19, data
on post-AKI kidney function recovery and the clinical factors associated with poor kidney …

The 21st Century Cures Act passed by the United States Congress mandates the US Food
and Drug Administration to develop guidance to evaluate the use of real‐world evidence (…

Background Admissions are generally classified as COVID-19 hospitalizations if the patient
has a positive SARS-CoV-2 polymerase chain reaction (PCR) test. However, because 35% …

The value of large-scale, real-world data—from electronic health records (EHRs), for
example—has been used to establish vaccine efficacy, to elucidate the genetic etiologies of …

What happens when an animal is injured and loses important structures? Some animals simply
heal the wound, whereas others are able to regenerate lost parts. In this study, we report …